Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan.

ABSTRACT: Although the effects of lead, mercury, manganese, and copper on individual disease processes are well understood, estimating the health effects of long-term exposure to these metals at the low concentrations often observed in the general population is difficult. In addition, the health effects of joint exposure to multiple metals are difficult to estimate. Biological aging refers to the integrative progression of multiple physiologic and molecular changes that make individuals more at risk of disease. Biomarkers of biological aging may be useful to estimate the population-level effects of metal exposure prior to the development of disease in the population. We used data from 290 participants in the Detroit Neighborhood Health Study to estimate the effect of serum lead, mercury, manganese,

SUBMITTER: Lodge EK 

PROVIDER: S-EPMC9620967 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature