Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis.

ABSTRACT: The aim of the present systematic review was to critically analyse the relationship between tumour suppressor genes (TSGs) promoter methylation, a potent mechanism of gene silencing, and the development of salivary gland tumours, as well as the possible effect on clinical/histological characteristics. Review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (registration ID CRD42020218511). A comprehensive search of Web of Science, Scopus, PubMed, and Cochrane Central Register of Controlled Trials was performed utilizing relevant key terms, supplemented by a search of grey literature. Newcastle-Ottawa Quality Assessment Scale (NOQAS) was used for the quality assessment of included studies. Sixteen cross-sectional and 12 case-control

SUBMITTER: Nikolic N 

PROVIDER: S-EPMC9620987 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature