Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome.

ABSTRACT: Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. However, much less is known about the mouse epigenome, particularly for DNA methylation. Progress in delivering mouse DNA methylomes has been slow due to the currently available time-consuming and expensive methodologies. Following the great acceptance of the human DNA methylation microarrays, we have herein validated a newly developed DNA methylation microarray (Infinium Mouse Methylation BeadChip) that interrogates 280,754 unique CpG sites within the mouse genome. The CpGs included in the platform cover CpG Islands, shores, shelves and open sea sequences, and

SUBMITTER: Garcia-Prieto CA 

PROVIDER: S-EPMC9621044 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature