The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity.

ABSTRACT: Frequently, patients with functional gastrointestinal disorders (FGIDs) report intolerance of wheat products. We compared gastrointestinal symptoms, sensory function, psychiatric comorbidities, gut-homing immune cells, and duodenal mucosa-associated microbiome (d-MAM) in FGID patients and controls with and without self-reported wheat sensitivity (SR-NCWS). We recruited 40 FGID patients and 20 controls referred by GPs for treatment. Gastrointestinal/extraintestinal symptoms, visceral sensory function, psychological comorbidities, and SR-NCWS were assessed in a standardized approach. Peripheral gut homing T-cells (CD4⁺α4⁺β7⁺CCR9⁺/CD8⁺α4⁺β7⁺CCR9⁺) were quantified, and the d-MAM was assessed by DNA sequenci

SUBMITTER: Shah A 

PROVIDER: S-EPMC9621048 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature