DNA methylation profiles in pneumonia patients reflect changes in cell types and pneumonia severity.

ABSTRACT: Immune cell-type composition changes with age, potentially weakening the response to infectious diseases. Profiling epigenetics marks of immune cells can help us understand the relationship with disease severity. We therefore leveraged a targeted DNA methylation method to study the differences in a cohort of pneumonia patients (both COVID-19 positive and negative) and unaffected individuals from peripheral blood.This approach allowed us to predict the pneumonia diagnosis with high accuracy (AUC = 0.92), and the PCR positivity to the SARS-CoV-2 viral genome with moderate, albeit lower, accuracy (AUC = 0.77). We were also able to predict the severity of pneumonia (PORT score) with an R² = 0.69. By estimating immune cellular frequency from DNA methylation data, patients under the a

SUBMITTER: Morselli M 

PROVIDER: S-EPMC9621067 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature