Systematic review and meta-analysis on the therapeutic reference range for escitalopram: Blood concentrations, clinical effects and serotonin transporter occupancy.

ABSTRACT:

Introduction

A titration within a certain therapeutic reference range presupposes a relationship between the blood concentration and the therapeutic effect of a drug. However, this has not been systematically investigated for escitalopram. Furthermore, the recommended reference range disagrees with mean steady state concentrations (11-21 ng/ml) that are expected under the approved dose range (10-20 mg/day). This work systematically investigated the relationships between escitalopram dose, blood levels, clinical effects, and serotonin transporter occupancy.

Methods

Following our previously published methodology, relevant articles were systematically searched and reviewed for escitalopram.

Results

Of 1,032 articles screened, a total of 30 studies met the eligibility cri

SUBMITTER: Eichentopf L 

PROVIDER: S-EPMC9621321 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature