Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review.

ABSTRACT:

Background/objectives

Immune-inflammatory changes have been found in all types of suicidal ideation and behavior (SIB), independently of associated mental disorders. Since several Single Nucleotide Polymorphisms (SNPs) affect the function of inflammation-related genes, we searched the literature for genetic variations potentially altering inflammatory processes in SIB.

Methods

We included studies that looked for associations between SIB and SNPs in genes related to inflammatory processes. Case reports, literature reviews, and animal studies were excluded. Articles were retrieved from PubMed and PsycINFO databases, Google Scholar and GreySource Index until September 17th, 2022. Quality was assessed using Q-Genie.

Results

We analyzed 32 studies. SIB has been associated

SUBMITTER: Tamimou R 

PROVIDER: S-EPMC9621324 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature