Proposed standardization of Neisseria meningitidis PorA variable-region typing nomenclature.

ABSTRACT: Neisseria meningitidis isolates are conventionally classified by serosubtyping, which characterizes the reactivities of the PorA outer membrane protein variable-region (VR) epitopes with monoclonal antibodies (MAbs). A newer method (PorA VR typing) uses predicted amino acid sequences derived from DNA sequence analysis. The resulting classification schemes are not standardized, offering conflicting and sometimes irreconcilable data from the two methods. In this paper, we propose a standardization of the PorA VR typing nomenclature that incorporates serologic information from traditional PorA serosubtyping with molecular data from predicted VR sequences. We performed a comprehensive literature and database search, generating a collection of strains and DNA sequences that reflects the diversi

SUBMITTER: Sacchi CT 

PROVIDER: S-EPMC96214 | biostudies-literature | 1998 Nov

REPOSITORIES: biostudies-literature