Association between cognitive function and large optic nerve cupping, accounting for cup-disc-ratio genetic risk score.

ABSTRACT:

Purpose

To investigate if accounting for a cup-to-disc ratio (CDR) genetic risk score (GRS) modified the association between large CDR and cognitive function among women.

Design

This was a retrospective study using data from the Women's Health Initiative.

Methods

Patients with glaucoma or ocular hypertension were excluded. Large CDR was defined as ≥ 0.6 in either eye. Cognitive function was measured by the Modified Mini-Mental State Examination (3MSE). We used the combined effects from 13 single nucleotide polymorphisms (SNPs) to formulate the GRS for CDR. We used logistic regression to investigate associations between weighted GRS and large CDR, then a linear regression to assess the association between weighted GRS and 3MSE scores, and between weighted GRS, CDR, and

SUBMITTER: Kravets S 

PROVIDER: S-EPMC9621414 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature