Radiation vs surgery for early-stage laryngeal verrucous carcinoma: A population-based propensity score matched-study.

ABSTRACT:

Background

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma. Although VC is considered radioresistant, concrete evidence for this is absent.

Methods

We obtained data on VC treated with surgery or radiation from the Surveillance, Epidemiology, and End Results database. Treatment selection bias was reduced by propensity score matching. Overall survival (OS) and disease-specific survival (DSS) rates were estimated using the Kaplan-Meier method. Hazard ratios (HRs) were estimated using Cox proportional hazards models.

Results

Five-year OS rates in the radiation and surgery groups were 72.7% and 72.0%, respectively (P = 0.111); five-year DSS rates in the same were 86.7% and 88.4%, respectively (P = 0.234). HRs of radiation compared with surgery were 1.

SUBMITTER: Takenaka Y 

PROVIDER: S-EPMC9621448 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature