Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke.

ABSTRACT:

Background

Early neurologic improvement (ENI) after intravenous thrombolysis is associated with favorable outcome, but associated serum biomarkers were not fully determined. We aimed to investigate the issue based on a prospective cohort.

Methods

In INTRECIS study, five centers were designed to consecutively collect blood sample from enrolled patients. The patients with ENI and without ENI were matched by propensity score matching with a ratio of 1:1. Preset 49 biomarkers were measured through microarray analysis. Enrichment of gene ontology and pathway, and protein-protein interaction network were analyzed in the identified biomarkers.

Results

Of 358 patients, 19 patients with ENI were assigned to ENI group, while 19 matched patients without ENI were assigned to Non

SUBMITTER: Cui Y 

PROVIDER: S-EPMC9621449 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature