High-dose corticosteroids in patients hospitalized for COVID-19 pneumonia: an observational study of comparative effectiveness.

ABSTRACT:

Objectives

To assess whether high- compared with low-dose corticosteroids started upon hospitalization reduce mortality in patients with severe COVID-19 pneumonia or in subgroups stratified by severity of respiratory impairment on admission.

Methods

We conducted a retrospective cohort study of patients with confirmed SARS-CoV-2 infection who required oxygen supplementation upon hospitalization between March 1 and December 31, 2020. In-hospital death was analyzed using logistic regression with inverse probability of treatment weighting of receiving low- or high-dose corticosteroid (dexamethasone 6-10 mg daily or >10-20 mg daily or other corticosteroid equivalents).

Results

We analyzed 13,366 patients who received low-dose and 948 who received high-dose corticosteroids,

SUBMITTER: Langer-Gould A 

PROVIDER: S-EPMC9621697 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature