Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.

ABSTRACT: SARS-CoV-2 remains an acute threat to human health, endangering hospital capacities worldwide. Previous studies have aimed at informing pathophysiologic understanding and identification of disease indicators for risk assessment, monitoring, and therapeutic guidance. While findings start to emerge in the general population, observations in high-risk patients with complex pre-existing conditions are limited. We addressed the gap of existing knowledge with regard to a differentiated understanding of disease dynamics in SARS-CoV-2 infection while specifically considering disease stage and severity. We biomedically characterized quantitative proteomics in a hospitalized cohort of COVID-19 patients with mild to severe symptoms suffering from different (co)-morbidities in comparison to both healt

SUBMITTER: Bauer A 

PROVIDER: S-EPMC9622026 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature