TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand.

ABSTRACT: A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.

SUBMITTER: Sodsai P 

PROVIDER: S-EPMC9622227 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature