SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice.

ABSTRACT: We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.

SUBMITTER: Baz M 

PROVIDER: S-EPMC9622237 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature