Cuproptosis, the novel therapeutic mechanism for heart failure: a narrative review.

ABSTRACT:

Background and objective

Heart failure (HF) is a global public health problem with high morbidity, readmission, and mortality rates. The central mediators of cardiomyocyte survival and death are mitochondria. Mitochondria are a key therapeutic target for HF and are closely involved in the pathophysiological process of HF. A recent study proposes that cuproptosis, a novel cell death mechanism, is closely related to mitochondrial respiration. Therefore, this study aims to explore the link between cuproptosis and HF, and to find novel therapeutic targets and treatments for HF.

Methods

A literature search (up to April 2022) was conducted through PubMed database, and the search range was limited to publications in English. After further literature search and screening, we found t

SUBMITTER: Yuan HJ 

PROVIDER: S-EPMC9622411 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature