Exploration of immune infiltration and feature genes in viral hepatitis-associated liver fibrosis using transcriptome data.

ABSTRACT:

Background

Immune cells play an essential role in virus-induced liver fibrosis. However, the underlying mechanisms remain unclear. In this study, we systematically explored immune cell infiltration and feature genes to provide new insights into viral hepatitis-associated liver fibrosis.

Methods

The expression datasets GSE14323, GSE33650, GSE6764 (for testing), and GSE84044 (for validation) were downloaded from the Gene Expression Omnibus (GEO) database. Immune cell infiltration was assessed using the CIBERSORT algorithm, and characteristic subgroups were obtained using least absolute shrinkage and selection operator (LASSO) regression and Wilcoxon test. The association between feature genes and immune-infiltrating cells was explored using Spearman's correlation analysis. R s

SUBMITTER: Pan J 

PROVIDER: S-EPMC9622482 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature