Identification of hub genes and infiltrating immune cells in skeletal muscle in obesity.

ABSTRACT:

Background

Metabolic syndrome (MetS) refers to a cluster of metabolic disorders that are mainly caused by obesity. Skeletal muscle is a central component of systemic metabolism. However, the mechanism of skeletal muscle metabolic impairment in obesity remains unclear. This study aimed to identify key early biomarkers in skeletal muscle for the prevention and treatment of MetS in obesity.

Methods

The GSE85439 dataset was downloaded from the Gene Expression Omnibus database. Gene set enrichment and immune cell infiltration analyses were performed for genome-wide genes. Differentially expressed genes (DEGs) between obese and control mice were screened and subjected to functional enrichment analysis, and a protein-protein interaction network was constructed. The results of the b

SUBMITTER: Jin S 

PROVIDER: S-EPMC9622484 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature