Impairments in goal-directed action and reversal learning in a proportion of individuals with psychosis.

ABSTRACT: Cognitive impairment in psychosis is one of the strongest predictors of functional decline. Problems with decision-making processes, such as goal-directed action and reversal learning, can reflect cortico-striatal dysfunction. The heterogenous symptoms and neurobiology observed in those with psychosis suggests that specific cognitive phenotypes may reflect differing causative mechanisms. As such, decision-making performance could identify subgroups of individuals with more severe cortico-striatal dysfunction and help to predict their functional decline. The present work evaluated the relationship between goal-directed action, reversal learning, and symptom profiles in those with psychosis. We assessed decision-making processes in healthy controls (N = 34) and those with persistent psychosi

SUBMITTER: Suetani S 

PROVIDER: S-EPMC9622547 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature