Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy.

ABSTRACT: Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric

SUBMITTER: Marlevi D 

PROVIDER: S-EPMC9622552 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature