Skin endothelial cell and microcirculation function study in recurred keloids patients after keloid surgery and radiotherapy.

ABSTRACT:

Background

Keloid is a type of benign tumor of the skin with abnormal proliferation of fibrous tissue. We sought to observe the changes in skin microcirculation and endothelial cell function around the recurred keloid and explore the skin microcirculation characters in recurred keloid patients.

Methods

Six patients with recurred keloid were treated with keloid surgery and radiotherapy for the second time. Microcirculation of recurred keloids and their surrounding normal skin tissue was observed with laser Doppler flowmeter before operation. Expression of vascular endothelial growth factor (VEGF), CD31, and HIF-1α were identified by several assay.

Results

The local blood flow of group RN was enhanced. The average strength of group N is 0.87. The average strength of gro

SUBMITTER: Li W 

PROVIDER: S-EPMC9622619 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature