Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.

ABSTRACT:

Background

Up to 80% of patients in the intensive care unit (ICU) suffer from delirium. Studies on the preventative use of melatonin in the ICU have produced mixed results. We performed a systematic review and meta-analysis to evaluate whether early administration of melatonin reduces the prevalence of delirium in critically ill patients.

Methods

We searched Medline, Embase, and the Cochrane Library for randomized controlled trials comparing melatonin or melatonin agonists to placebo in ICU setting. The population included adult patients in the ICU. The primary outcome was the prevalence of delirium. Secondary outcomes included duration of delirium, delirium-free day, serum melatonin concentration, need for sedation, duration of mechanical ventilation, hospital and ICU lengt

SUBMITTER: Yan W 

PROVIDER: S-EPMC9622662 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature