Effect of ¹³¹I with and without artificial liver support system in patients with Graves' disease and severe liver dysfunction: A retrospective study.

ABSTRACT:

Objective

Treatment decision-making in Graves' disease (GD) with severe liver dysfunction (LD) is a clinical challenge. This research was carried out to evaluate the effect of radioiodine (¹³¹I) with or without an artificial liver support system (ALSS) in GD patients with severe LD.

Methods

In total, 45 patients diagnosed with GD and severe LD were enrolled and allocated to two groups: patients treated with ¹³¹I alone (n=30) (Group A)and patients by a combination of ¹³¹I and ALSS (n=15)(Group B). Liver function, thyroid hormone concentrations, therapeutic efficacy, and the cost of treatment were compared between the two groups.

Results

Thyroid hormone concentrations were lower 2 weeks after ¹³¹I treatment, but no deteriorati

SUBMITTER: Rao M 

PROVIDER: S-EPMC9622763 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature