The CaT stretcher: An open-source system for delivering uniaxial strain to cells and tissues (CaT).

ABSTRACT: Integration of mechanical cues in conventional 2D or 3D cell culture platforms is an important consideration for in vivo and ex vivo models of lung health and disease. Available commercial and published custom-made devices are frequently limited in breadth of applications, scalability, and customization. Herein we present a technical report on an open-source, cell and tissue (CaT) stretcher, with modularity for different in vitro and ex vivo systems, that includes the following features: 1) Programmability for modeling different breathing patterns, 2) scalability to support low to high-throughput experimentation, and 3) modularity for submerged cell culture, organ-on-chips, hydrogels, and live tissues. The strategy for connecting the experimental cell or tissue

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9622803 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature