Formation of supramolecular channels by reversible unwinding-rewinding of bis(indole) double helix via ion coordination.

ABSTRACT: Stimulus-responsive reversible transformation between two structural conformers is an essential process in many biological systems. An example of such a process is the conversion of amyloid-β peptide into β-sheet-rich oligomers, which leads to the accumulation of insoluble amyloid in the brain, in Alzheimer's disease. To reverse this unique structural shift and prevent amyloid accumulation, β-sheet breakers are used. Herein, we report a series of bis(indole)-based biofunctional molecules, which form a stable double helix structure in the solid and solution state. In presence of chloride anion, the double helical structure unwinds to form an anion-coordinated supramolecular polymeric channel, which in turn rewinds upon the addition of Ag⁺ salts. Moreover, the formation of the ani

SUBMITTER: Mondal D 

PROVIDER: S-EPMC9622825 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature