Blood-brain barrier and brain structural changes in lung cancer patients with non-brain metastases.

ABSTRACT:

Purpose

To explore the relationship between blood-brain barrier (BBB) leakage and brain structure in non-brain metastasis lung cancer (LC) by magnetic resonance imaging (MRI) as well as to indicate the possibility of brain metastasis (BM) occurrence.

Patients and methods

MRI were performed in 75 LC patients and 29 counterpart healthy peoples (HCs). We used the Patlak pharmacokinetic model to calculate the average leakage in each brain region according to the automated anatomical labeling (AAL) atlas. The thickness of the cortex and the volumes of subcortical structures were calculated using the FreeSurfer base on Destrieux atlas. We compared the thickness of the cerebral cortex, the volumes of subcortical structures, and the leakage rates of BBB, and evaluated the relationsh

SUBMITTER: Zhang DF 

PROVIDER: S-EPMC9623018 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature