Improving predictive performance in incident heart failure using machine learning and multi-center data.

ABSTRACT:

Objective

To mitigate the burden associated with heart failure (HF), primary prevention is of the utmost importance. To improve early risk stratification, advanced computational methods such as machine learning (ML) capturing complex individual patterns in large data might be necessary. Therefore, we compared the predictive performance of incident HF risk models in terms of (a) flexible ML models and linear models and (b) models trained on a single cohort (single-center) and on multiple heterogeneous cohorts (multi-center).

Design and methods

In our analysis, we used the meta-data consisting of 30,354 individuals from 6 cohorts. During a median follow-up of 5.40 years, 1,068 individuals experienced a non-fatal HF event. We evaluated the predictive performance of survival gra

SUBMITTER: Sabovcik F 

PROVIDER: S-EPMC9623026 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature