CBAF complex components and MYC cooperate early in CD8⁺ T cell fate.

ABSTRACT: The identification of mechanisms to promote memory T (T_mem) cells has important implications for vaccination and anti-cancer immunotherapy^1-4. Using a CRISPR-based screen for negative regulators of T_mem cell generation in vivo⁵, here we identify multiple components of the mammalian canonical BRG1/BRM-associated factor (cBAF)^6,7. Several components of the cBAF complex are essential for the differentiation of activated CD8⁺ T cells into T effector (T_eff) cells, and their loss promotes T_mem cell formation in vivo. During the first division of activated CD8⁺ T cells, cBAF and MYC⁸ frequently co-assort asymmetrically to the two daughter cells. Daughter cells with high MYC and high cBAF

SUBMITTER: Guo A 

PROVIDER: S-EPMC9623036 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature