Causal association between rheumatoid arthritis and celiac disease: A bidirectional two-sample mendelian randomization study.

ABSTRACT: Objectives: Rheumatoid Arthritis (RA) has been associated with Celiac Disease (CD) in previous observational epidemiological studies. However, evidence for this association is limited and inconsistent, and it remains uncertain whether the association is causal or due to confounding or reverse causality. This study aimed to assess the bidirectional causal relationship between RA and CD. Methods: In this two-sample Mendelian randomization (MR) study, instrumental variables (IVs) for RA were derived from a genome-wide association studies (GWAS) meta-analysis including 58,284 subjects. Summary statistics for CD originated from a GWAS meta-analysis with 15,283 subjects. The inverse-variance weighted (IVW) method was used as the primary analysis. Four complementary methods were app

SUBMITTER: Hua L 

PROVIDER: S-EPMC9623103 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature