Exploring the immunomodulatory role of virtual memory CD8⁺ T cells: Role of IFN gamma in tumor growth control.

ABSTRACT: Virtual memory CD8⁺ T cells (T_VM) have been described as cells with a memory-like phenotype but without previous antigen (Ag) exposure. T_VM cells have the ability to respond better to innate stimuli rather than by TCR engagement, producing large amounts of interferon gamma (IFNγ) after stimulation with interleukin (IL)-12 plus IL-18. As a result of the phenotypic similarity, T_VM cells have been erroneously included in the central memory T cell subset for many years. However, they can now be discriminated via the CD49d receptor, which is up-regulated only on conventional memory T cells (T_MEM) and effector T cells (T_EFF) after specific cognate Ag recognition by a TCR. In this work we show that systemic expression of IL-

SUBMITTER: Savid-Frontera C 

PROVIDER: S-EPMC9623162 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature