Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis.

ABSTRACT:

Objective

Testicular germ cell tumors (TGCT) are the most common solid malignancy in adolescent and young men, with a rising incidence over the past 20 years. Overall, TGCTs are second in terms of the average life years lost per person dying of cancer, and clinical therapeutics without adverse long-term side effects are lacking. Platinum-based regimens for TGCTs have heterogeneous outcomes even within the same histotype that frequently leads to under- and over-treatment. Understanding of molecular differences that lead to diverse outcomes of TGCT patients may improve current treatment approaches. Seminoma is the most common subtype of TGCTs, which can either be pure or present in combination with other histotypes.

Methods

Here we conducted a computational study of 64 pure se

SUBMITTER: Medvedev KE 

PROVIDER: S-EPMC9623390 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature