Association of Vaginal Progesterone Treatment With Prevention of Recurrent Preterm Birth.

ABSTRACT:

Importance

Preterm birth (PTB) is the leading cause of infant morbidity and mortality worldwide. It has been suggested that vaginal progesterone (VP) treatment may reduce the recurrence of PTB.

Objective

To evaluate the association of VP treatment with prevention of recurrent PTB among patients with a singleton pregnancy.

Design, setting, and participants

This prospective, observational cohort study, set in a public health care system for inner-city pregnant patients, enrolled patients with prior spontaneous PTB (gestational age, ≤35 weeks) receiving VP from May 15, 2017, to May 7, 2019. Patients who delivered between 1998 and 2011 served as a referent cohort matched 3:1 for obesity, race and ethnicity, and individual specific preterm birth history. Statistical analys

SUBMITTER: Nelson DB 

PROVIDER: S-EPMC9623441 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature