Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain.

ABSTRACT: Neuropathic pain affects 7-10% of the adult population. Being able to accurately monitor biological changes underlying neuropathic pain will improve our understanding of neuropathic pain mechanisms and facilitate the development of novel therapeutics. Positron emission tomography (PET) is a noninvasive molecular imaging technique that can provide quantitative information of biochemical changes at the whole-body level by using radiolabeled ligands. One important biological change underlying the development of neuropathic pain is the overexpression of α2δ-1 subunit of voltage-dependent calcium channels (the target of gabapentin). Thus, we hypothesized that a radiolabeled form of gabapentin may allow imaging changes in α2δ-1 for monitoring the underlying pathophysiology of neuropathic pain. H

SUBMITTER: Zhou YP 

PROVIDER: S-EPMC9623503 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature