Up-regulation of CB₁ cannabinoid receptors located at glutamatergic terminals in the medial prefrontal cortex of the obese Zucker rat.

ABSTRACT: The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB₁) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G _i/o proteins in the medial prefrontal cortex (mPCx) of the obese Zucker rats. The CB₁ receptor density was higher in the prelimbic (PL) and infralimbic (IL) subregions of the mPCx of obese Zucker rats relative to their lean littermates which was associated with a higher percentage of CB₁ receptor immunopositive excitatory presynaptic terminals in PL and IL. Also, a higher expression of CB₁ receptors and WIN55,212-2-stimulated [³⁵S]GTPγS binding was observed in the mPCx but not in the neocortex (NCx) and

SUBMITTER: Echeazarra L 

PROVIDER: S-EPMC9623818 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature