The combined impact of persistent infections and human genetic variation on C-reactive protein levels.

ABSTRACT: Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomplete understanding of the potential contribution of both persistent infections and human genetic variation on chronic low-grade inflammation. We searched for potential associations between seropositivity for 13 persistent pathogens and the plasma levels of the inflammatory biomarker C-reactive protein (CRP), using data collected in the context of the UK Biobank and the CoLaus|PsyCoLaus Study, two large population-based cohorts. We performed backward stepwise regression starting with the following potential predictors: serostatus for each pa

SUBMITTER: Hodel F 

PROVIDER: S-EPMC9623937 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature