Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.

ABSTRACT:

Background

Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships are causal, and whether the risk factors act independently of each other. The aim of this study was to investigate putative causal relationships between the number of live births, age at last live birth, and years ovulating and EC risk.  METHODS: We conducted a series of observational analyses to investigate various risk factors and EC risk in the UK Biobank (UKBB). Additionally, multivariate analysis was performed to elucidate the relationship between the number of live births, age at last live birth, and years ovulating and other related factors such as age at n

SUBMITTER: D'Urso S 

PROVIDER: S-EPMC9623961 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature