Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry.

ABSTRACT: Exposure to traffic-related pollutants, including diesel exhaust, is associated with increased risk of cardiopulmonary disease and mortality; however, the precise biochemical pathways underlying these effects are not known. To investigate biological response mechanisms underlying exposure to traffic related pollutants, we used an integrated molecular response approach that included high-resolution metabolomic profiling and peripheral blood gene expression to identify biological responses to diesel exhaust exposure. Plasma samples were collected from 73 non-smoking males employed in the US trucking industry between February 2009 and October 2010, and analyzed using untargeted high-resolution metabolomics to characterize metabolite associations with shift- and week-averaged levels of element

SUBMITTER: Walker DI 

PROVIDER: S-EPMC9624233 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature