Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.

ABSTRACT:

Purpose

Integrating polygenic risk scores (PRS) into healthcare has the potential to stratify an individual's risk of glaucoma across a broad population. Glaucoma is the most common cause of irreversible blindness worldwide, therefore effective screening for glaucoma endorsed by the population is highly important. This study assessed the attitude of unaffected individuals toward PRS testing for glaucoma, and sought to identify factors associated with interest in testing.

Methods

We surveyed 418 unaffected individuals including 193 with a first-degree relative with glaucoma, 117 who had a recent eye examination, and 108 general members of the community.

Results

Overall, 71.3% of the individuals indicated an interest in taking a polygenic risk test for glaucoma. Interes

SUBMITTER: Hollitt GL 

PROVIDER: S-EPMC9624267 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature