The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn's Disease.

ABSTRACT:

Background and aims

Crohn's disease [CD] is associated with complex microbe-host interactions, involving changes in microbial communities, and gut barrier defects, leading to the translocation of microorganisms to surrounding adipose tissue [AT]. We evaluated the presence of beige AT depots in CD and questioned whether succinate and/or bacterial translocation promotes white-to-beige transition in adipocytes.

Methods

Visceral [VAT] and subcutaneous [SAT] AT biopsies, serum and plasma were obtained from patients with active [n = 21] or inactive [n = 12] CD, and from healthy controls [n = 15]. Adipose-derived stem cells [ASCs] and AT macrophages [ATMs] were isolated from VAT biopsies.

Results

Plasma succinate levels were significantly higher in patients with active CD th

SUBMITTER: Monfort-Ferre D 

PROVIDER: S-EPMC9624294 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature