Combined Traction Force-Atomic Force Microscopy Measurements of Neuronal Cells.

ABSTRACT: In the course of the development of the nervous system, neuronal cells extend (grow) axons, which navigate over distances of the order of many cell diameters to reach target dendrites from other neurons and establish neuronal circuits. Some of the central challenges in biophysics today are to develop a quantitative model of axonal growth, which includes the interactions between the neurons and their growth environment, and to describe the complex architecture of neuronal networks in terms of a small number of physical variables. To address these challenges, researchers need new experimental techniques for measuring biomechanical interactions with very high force and spatiotemporal resolutions. Here we report a unique experimental approach that integrates three different high-resolution tec

SUBMITTER: Kumarasinghe U 

PROVIDER: S-EPMC9624305 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature