Glycolytic activity in human immune cells: inter-individual variation and functional implications during health and diabetes.

ABSTRACT: An increase in glucose uptake driving aerobic glycolysis is a robust hallmark of immune cell activation. The glycolytic response supports functional alterations of the innate immune cells including the production and release of cytokines. Large inter-individual differences in the magnitude of this cytokine response are known to exist. In addition, the presence of disease is known to impact on immune cell function. Whether variation in metabolic responses of immune cells exist between individuals during health or disease is currently unknown. Here, we explore inter-individual differences in the glycolytic rate of immune cells using lactate production as readout upon activation using a variety of different stimuli. Glycolytic responses are subsequently associated to functional immune cell re

SUBMITTER: Vrieling F 

PROVIDER: S-EPMC9624385 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature