Duodenal Permeability Is Associated With Mucosal Microbiota in Compensated Cirrhosis.

ABSTRACT:

Introduction

Several complications of decompensated cirrhosis are believed to result from increased intestinal permeability. However, little is known about the relationship between mucosal bacteria and epithelial permeability in cirrhosis. We aimed to assess epithelial permeability and associations with mucosal bacteria in patients with compensated cirrhosis.

Methods

We obtained duodenal tissue biopsies from patients with compensated cirrhosis and controls. Patients were excluded if they used antibiotics or immunosuppression. The composition of mucosal microbiota was determined by 16S rRNA gene sequencing and epithelial permeability by transepithelial electrical resistance (TEER) and tight junction protein expression.

Results

We studied 24 patients with compensated ci

SUBMITTER: Bloom PP 

PROVIDER: S-EPMC9624490 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature