Fiber Ball White Matter Modeling Reveals Microstructural Alterations in Healthy Brain Aging.

ABSTRACT: Age-related white matter degeneration is characterized by myelin breakdown and neuronal fiber loss that preferentially occur in regions that myelinate later in development. Conventional diffusion MRI (dMRI) has demonstrated age-related increases in diffusivity but provide limited information regarding the tissue-specific changes driving these effects. A recently developed dMRI biophysical modeling technique, Fiber Ball White Matter (FBWM) modeling, offers enhanced biological interpretability by estimating microstructural properties specific to the intra-axonal and extra-axonal spaces. We used FBWM to illustrate the biological mechanisms underlying changes throughout white matter in healthy aging using data from 63 cognitively unimpaired adults ages 45-85 with no radiological evidence of ne

SUBMITTER: Dhiman S 

PROVIDER: S-EPMC9624504 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature