Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels.

ABSTRACT:

Background

The harmful vascular effects of smoking are well established, but the effects of chronic use of electronic cigarettes (e-cigarettes) on endothelial function are less understood. We hypothesized that e-cigarette use causes changes in blood milieu that impair endothelial function.

Methods

Endothelial function was measured in chronic e-cigarette users, chronic cigarette smokers, and nonusers. We measured effects of participants' sera, or e-cigarette aerosol condensate, on NO and H₂O₂ release and cell permeability in cultured endothelial cells (ECs).

Results

E-cigarette users and smokers had lower flow-mediated dilation (FMD) than nonusers. Sera from e-cigarette users and smokers reduced VEGF (vascular endothelial growth factor)-induced NO

SUBMITTER: Mohammadi L 

PROVIDER: S-EPMC9625085 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature