Assessing the Mechanism of Action of "Fructus Ligustri Lucidi-Cuscutae Semen" in Prostate Cancer Treatment Using Network Pharmacology and Molecular Docking.

ABSTRACT:

Objective

To explore the mechanism of action of "Fructus Ligustri Lucidi-Cuscutae Semen" in the treatment of prostate cancer using network pharmacology and molecular docking.

Methods

The active ingredients and targets of "Fructus Ligustri Lucidi-Cuscutae Semen" were obtained by searching the TCMSP and DrugBank databases. These were matched and corrected using the UniProt platform. A drug "active ingredient-target" network map was constructed using Cytoscape 3.8.0. Prostate cancer-related targets were acquired from GeneCards, Disgenet, DrugBank, and other databases. The protein-protein interaction (PPI) network between the drug and prostate cancer was constructed with BioGenet; the crossover network of the two targets was extracted derive the key targets of "Fructus Ligustri

SUBMITTER: Lu D 

PROVIDER: S-EPMC9626213 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature