Immunomodulatory therapy using a pediatric dialysis system ameliorates septic shock in miniature pigs.

ABSTRACT:

Background

Application of the immunomodulatory selective cytopheretic device (SCD) to enhance renal replacement therapy and improve outcomes of acute kidney injury in pediatric patients is impeded by safety concerns. Therapy using a pediatric hemodialysis system could overcome these limitations.

Methods

Yucatan minipigs (8-15 kg) with induced septic shock underwent continuous hemodiafiltration with the CARPEDIEM™ pediatric hemodialysis system using regional citrate anticoagulation (RCA) with or without SCD (n = 5 per group). Circuit function plus hemodynamic and hematologic parameters were assessed for 6 h.

Results

SCD was readily integrated into the CARPEDIEM™ system and treatment delivered for 6 h without interference with pump operation. SCD-treated pigs maintained

SUBMITTER: Johnston KA 

PROVIDER: S-EPMC9626391 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature