Quantitative Apparent Diffusion Coefficients From Peritumoral Regions as Early Predictors of Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer.

ABSTRACT:

Background

Pathologic complete response (pCR) to neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC) is a strong predictor of patient survival. Edema in the peritumoral region (PTR) has been reported to be a negative prognostic factor in TNBC.

Purpose

To determine whether quantitative apparent diffusion coefficient (ADC) features from PTRs on reduced field-of-view (rFOV) diffusion-weighted imaging (DWI) predict the response to NAST in TNBC.

Study type

Prospective.

Population/subjects

A total of 108 patients with biopsy-proven TNBC who underwent NAST and definitive surgery during 2015-2020.

Field strength/sequence

A 3.0 T/rFOV single-shot diffusion-weighted echo-planar imaging sequence (DWI).

Assessment

Three scans were acqu

SUBMITTER: Musall BC 

PROVIDER: S-EPMC9626398 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature