Host-microbiome interactions: Gut-Liver axis and its connection with other organs.

ABSTRACT: An understanding of connections between gut microbiome and liver has provided important insights into the pathophysiology of liver diseases. Since gut microbial dysbiosis increases gut permeability, the metabolites biosynthesized by them can reach the liver through portal circulation and affect hepatic immunity and inflammation. The immune cells activated by these metabolites can also reach liver through lymphatic circulation. Liver influences immunity and metabolism in multiple organs in the body, including gut. It releases bile acids and other metabolites into biliary tract from where they enter the systemic circulation. In this review, the bidirectional communication between the gut and the liver and the molecular cross talk between the host and the microbiome has been discussed. This r

SUBMITTER: Anand S 

PROVIDER: S-EPMC9626460 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature