Persistence of plasmid and tet(X4) in an Escherichia coli isolate coharboring bla _NDM-5 and mcr-1 after acquiring an IncFII tet(X4)-positive plasmid.

ABSTRACT: The prevalence of plasmid-mediated tigecycline resistance gene tet(X4) is presenting an increasing trend. Once tet(X4)-bearing plasmids are captured by multidrug-resistant bacteria, such as bla _NDM and mcr-coharboring bacteria, it will promote bacteria to develop an ultra-broad resistance spectrum, limiting clinical treatment options. However, little is known about the destiny of such bacteria or how they will evolve in the future. Herein, we constructed a multidrug-resistant bacteria coharboring tet(X4), bla _NDM-5, and mcr-1 by introducing a tet(X4)-bearing plasmid into a bla _NDM-5 and mcr-1 positive E. coli strain. Subsequently, the stability of tet(X4) and the plasmid was

SUBMITTER: Xiao X 

PROVIDER: S-EPMC9626518 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature