Orofacial abnormalities in mucopolysaccharidosis and mucolipidosis type II and III: A systematic review.

ABSTRACT: Mucopolysaccharidoses (MPSs) and mucolipidosis II and III (ML II and III) often manifest with orofacial (progressive) abnormalities, which may have a major impact on quality of life. However, because these patients have multiple somatic health issues, orofacial problems are easily overlooked in clinical practice and available literature on this topic solely consists of case reports, small case series, and small cohort studies. The aim of this systematic review was to gain more insight in the nature and extent of orofacial abnormalities in MPS, ML II, and III. A systematic review of all previously published articles addressing orofacial abnormalities in MPS, ML II, and III was performed. Both clinical studies and case reports were included. Outcome was the described orofacial abnormalities,

SUBMITTER: de Bode CJ 

PROVIDER: S-EPMC9626671 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature